ABOUT US
SKINTARGET
Skintarget Biological Developments SL (SKINTARGET) is a biotech start-up focused on Research & Development of innovative, breaking, marketable technologies and products for skin care and regeneration.
WORKING ON:
- Cosmetic skin care and regeneration
- Eco-sustainable sunscreens
- Skin antiaging and antipollution
- Therapeutic skin regeneration
- Chronic wounds and ulcers
- Psoriasis and atopic dermatitis
- Skin care in oncological patients
Located at Universidad Francisco de Vitoria (Madrid)
SKIN REGENERATION MARKET
Dermocosmetics and Regenerative Medicine.
SKIN REGENERATION MARKET: NICHES
Current needs in the skin care and regeneration market define hot-spot R&D niches:
RESEARCH
SKINTARGET proposal to become a competitive and suitable partner for dermatology and cosmetic market players is based on a unique, innovative technology supported by more than 15 years of previous experimental work.
This technology relies on the controlled photonic activation of a transient production of stimulating reactive oxygen species (ROS) levels in mammalian cells and tissues.
A) The photodynamic process for a controlled ROS production, involving three elements: a photosensible molecule (PS), light and molecular oxygen. Absorption of adequate wavelength photons by the PS induces a transition to an excited state. Dynamic return of the PS to a background state implies electron transfer to molecular oxygen and the generation of ROS
B) Using the PS Protoporphyrin IX (PpIX) molecule, present in the mitochondria of most mammalian cells, for a controlled activation of endogenous ROS production. Excitation of PpIX with Red light induces ROS production. A suitable combination of red-light irradiation doses and PpIX precursors (ALA: aminolevulinic acid; mALA: methylaminolevulinate) in the presence of molecular oxygen results in a non-lethal ROS production in the cell.
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At present, we have two main R&D lines:
PHOTOSKIN
Highly-efficient, topical-use, eco-friendly compositions for photoprotection, antiaging and skin regeneration
(PCT/ES2023/070306)
Critical Innovation: Using the process of Sequential Photonic Transfer between organic compounds of plant origin to transform UV light into skin-stimulating red light.
PHOTOCURE
Ergonomic, user friendly, flexible LED + topic hydrogel device for rapid healing of chronic wounds and ulcers
(Patent application in process)
Critical Innovation: Using a unique synergic combination of infrared light and eco-sustainable plant compounds to directly activate the production of stimulating ROS in cells and tissues.
PHOTOSKIN TECHNOLOGY
Winner Cantabria Labs Celebrate Innovation 2022 Award-Photobiology
The PHOTOSKIN technology is based on the breaking concept of Sequential Photonic Transfer between adjacent organic compounds.
Take a sunbath to regenerate your skin
The Sequential Photonic Transfer process implemented for topical use in the skin, whereby an organic molecule (or mix) A on the epidermal surface absorbs deleterious UV photons (PHOTOPROTECTIVE EFFECT), emitting blue-light photons, and an adjacent organic molecule (or mix) B absorbs blue-light photons emitting red-light photons.
Red-light photons can easily cross the skin barrier an interact with an endogenous photosensitizer C, typically PpIX, activating a ROS-dependent homeostatic program of skin regeneration (SKIN REGENERATION EFFECT).
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REGULATORY STRATEGY
The regulatory strategy for PHOTOSKIN-based products to lay the ground for further manufacturing in GMP conditions involves registration of functionally validated prototypes as cosmetics following EU Legislation (Cosmetics Regulation (EC) Nº 1223/2009).
Registration requires safety validation testing of the following standard conditions:
BUSINESS PLAN
SERVICES
We are experts in experimental skin testing.
We may evaluate and characterize, at your required cell, molecular and /or tissue resolution level, the skin response (toxicity, stimulation, protection, etc.) to organic or inorganic molecules of your choice using different experimental models:
- Primary skin cell cultures
- Organotypic cultures of human skin
- Human Hair follicles “ex vivo”
- Physiological mouse skin
- Wound and burn healing in mouse skin
- Mouse models of cutaneous diseases (e.g., psoriasis, atopic dermatitis)
- “In vitro” UV photoprotection testing
We implement each experimental design to fit with your needs, optimising output results to obtain high quality information.
Some examples:
–Cryptomphalus aspersa mollusc eggs extract promotes migration and prevents cutaneous ageing in keratinocytes and dermal fibroblasts in vitro. (Espada J. et al. Int. J. Cosmetic Sci., 2015)
–Sustained Human Hair Follicle Growth Ex Vivo in a Glycosaminoglycan Hydrogel Matrix (Fernandez-Martos S. et al. Int. J. Mol. Sci., 2019)
–A role for the Tgf-β/Bmp co-receptor Endoglin in the molecular oscillator that regulates the hair follicle cycle (Calvo-Sanchez et al. J. Mol. Cell. Biol., 2019)
–The deleterious effects induced by an acute exposure of human skin to common air pollutants are prevented by extracts of Deschampsia Antarctica (Fernandez-Martos S. et al. Sci. Rep, 2021)
CONTACT US
JESÚS ESPADA
Co-founder
CSO. General Manager
Research & Development
PhD in Biological Sciences
+34 677 49 59 70
jesus.espada@skintargetbd.com
OUR SPECIALISTS
Research & Development.
PhD in Biological Sciences.
Research & Development.
BS and Master in Molecular Biology.
Market and Business development.
BS in Mount Engineering.
Clinical Advisor. Cosmetic Dermatology, Ruber International Hospital, Clinica Dermoscosmética Internacional Madrid
BS in Medicine
Research & Development.
PhD Student
Research & Development.
PhD Student
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