ABOUT US

SKINTARGET

Skintarget Biological Developments SL (SKINTARGET) is a biotech start-up focused on Research & Development of innovative, breaking, marketable technologies and products for skin care and regeneration.

WORKING ON:

  • Cosmetic skin care and regeneration
  • Eco-sustainable sunscreens
  • Skin antiaging and antipollution
  • Therapeutic skin regeneration
  • Chronic wounds and ulcers
  • Psoriasis and atopic dermatitis
  • Skin care in oncological patients

Located at Madrid Scientific Park (Madrid)

SKIN REGENERATION MARKET

Dermocosmetics and Regenerative Medicine.
The NEEDS exist for the development of breaking products for skin care and regeneration showing real effectiveness.

MISSION AND VISION

Our mission is to act as a factory of ideas that generates innovative and ground-breaking intellectual property for skin regeneration

We aim to develop breakthrough, highly effective technologies to improve human well-being and alleviate the socioeconomic burden of skin-related conditions by effectively translating lab research ideas into practical real-world applications.

Quality, eco-sustainability, and respect for the environment are the principles that guide our behavior and actions.

Our approach involves identifying critical problems, designing innovative solutions, validating hypotheses through rigorous experimentation, and developing functional prototypes.

Our vision is to achieve a leadership position in the global market for disruptive biotechnology products for skin regeneration and care by securing the licensing of our products to leading companies in the sector.

Our ambition is to create new research lines that ensure our leadership in skin care and regeneration solutions, making our company a benchmark for attracting top talent in the field of research.

Through strategic growth and collaboration, SKINTARGET aims to make significant contributions to the fields of dermocosmetics and regenerative medicine, providing effective, sustainable, and cutting-edge solutions for skin care”

SKIN REGENERATION MARKET: NICHES

Current needs in the skin care and regeneration market define hot-spot R&D niches:

Dermocosmetics

Eco friendly products for photoprotection and skin regeneration

  • Most available sunscreens are based on physical (e.g. titanium dioxide) or chemical (e. g. oxybenzone, avobenzone, octisalate, octocrylene, homosalate, and octinoxate) filters, synthetic compounds that may be harmful to both the user and the environment.
  • Most anti-aging and skin regeneration cosmetics available on the market are moisturizing formulations containing a set of additional molecules that are presumed to act in the dermis.
  • Some of these molecules (e.g., collagen, coenzyme Q10, or hyaluronic acid) exhibit very low penetration into the epidermis due to their molecular size or hydrophilicity, resulting in minimal physiological effects.
  • Only small hydrophobic molecules, atoms or subatomic particles, e. g. photons, can effectively cross the skin barrier.
  • Retinol (Vitamin A), a small hydrophobic molecule able to cross the skin barrier promoting beneficial effects in the skin, is at present the “golden” active ingredient in anti-ageing dermocosmetics.
  • The effectiveness of topically applied retinol depends on its concentration. However, excessive cumulative exposure to Vitamin A/Retinol from diet, supplements, and skincare can cause foetal abnormalities as well as skin and liver damage. Consequently, the EU will limit dermocosmetics to 0.3% retinol, a level that significantly reduces its efficacy.
  • Additionally, the accumulation of residual synthetic retinol, which is predominantly used in dermocosmetics, may have a severe environmental impact in the medium to long term.

Regenerative Medicine

Healing of chronic wounds and ulcers 

(Elder and/or diabetic patients or chronic surgical wound) 

  • No effective therapies.
  • These lesions can persist for months or even years, showing little or no tendency to heal, causing pain and social distress. 
  • The global economic cost is measured in billions of euros. These lesions can account for almost 4-8% of total health system budget in western countries and this proportion is increasing. 

SKINTARGET

Is positioned in two fastest-growing areas of the skin care and regeneration biotechnological market :

 Dermocosmetics and Regenerative Medicine.

RESEARCH


SKINTARGET proposal to become a competitive and suitable partner for dermatology and cosmetic market players is based on a unique, innovative technology supported by more than 15 years of previous experimental work.

This technology relies on the controlled photonic activation of a transient production of stimulating reactive oxygen species (ROS) levels in mammalian cells and tissues.

 

A) The photodynamic process for a controlled ROS production, involving three elements: a photosensible molecule (PS), light and molecular oxygen.  Absorption of adequate wavelength photons by the PS induces a transition to an excited state. Dynamic return of the PS to a background state implies electron transfer to molecular oxygen and the generation of ROS

 

B) Using the PS Protoporphyrin IX (PpIX) molecule, present in the mitochondria of most mammalian cells, for a controlled activation of endogenous ROS production. Excitation of PpIX with Red light induces ROS production. A suitable combination of red-light irradiation doses and PpIX precursors (ALA: aminolevulinic acid; mALA: methylaminolevulinate) in the presence of molecular oxygen results in a non-lethal ROS production in the cell.

Click on image for a larger view

At present, we have two main R&D lines:

PHOTOSKIN

Highly-efficient, topical-use, eco-friendly compositions for photoprotection, antiaging  and skin regeneration

(PCT/ES2023/070306)

Critical Innovation: Using the process of Sequential Photonic Transfer between organic compounds of plant origin to transform UV light into skin-stimulating red light.

PHOTOCURE

Ergonomic, user friendly, flexible LED + topic hydrogel device for rapid healing of chronic wounds and ulcers

(Patent application in process)

Critical Innovation: Using a unique synergic combination of infrared light and eco-sustainable plant compounds to directly activate the production of stimulating ROS  in cells and tissues.

PHOTOSKIN TECHNOLOGY


Winner Cantabria Labs Celebrate Innovation 2022 Award-Photobiology

The PHOTOSKIN technology is based on the breaking concept of Sequential Photonic Transfer between adjacent organic compounds.

Take a sunbath to regenerate your skin

The Sequential Photonic Transfer process implemented for topical use in the skin, whereby an organic molecule (or mix) A on the epidermal surface absorbs deleterious UV photons (PHOTOPROTECTIVE EFFECT), emitting blue-light photons, and an adjacent organic molecule (or mix) B absorbs blue-light photons emitting red-light photons. 

Red-light photons can easily cross the skin barrier an interact with an endogenous photosensitizer C, typically PpIX, activating a ROS-dependent homeostatic program of skin regeneration (SKIN REGENERATION EFFECT).

Click on image for a larger view

REGULATORY STRATEGY


The regulatory strategy for PHOTOSKIN-based products to lay the ground for further manufacturing in GMP conditions involves registration of functionally validated prototypes as cosmetics following EU Legislation (Cosmetics Regulation (EC) Nº 1223/2009).

Registration requires safety validation testing of the following standard conditions:

BUSINESS PLAN

Factory of ideas

SkinTarget BD aims is to work as a factory of ideas rather than as large scale production and/or final distribution company.

Business plan

Our basic business plan consist in the licensing to target companies the exclusive use of new technologies/marketable prototypes showing a high commercial interest, and further royalty on sales dale

Work plan

Our work plan consist in the development of technologies and prototypes to a 5-8 Technology Readiness Level and further exposition to market through intensive marketing, communication and direct contact campaigns.

Regulatory Strategy

Product registration as cosmetic in UE/NA

SERVICES


 

We are experts in experimental skin testing.

We may evaluate and characterize, at your required cell, molecular and /or tissue resolution level, the skin response (toxicity, stimulation, protection, etc.) to organic or inorganic molecules of your choice using different experimental models:

  • Primary skin cell cultures
  • Organotypic cultures of human skin
  • Human Hair follicles “ex vivo”
  • Physiological mouse skin
  • Wound and burn healing in mouse skin
  • Mouse models of cutaneous diseases (e.g., psoriasis, atopic dermatitis)
  • “In vitro” UV photoprotection testing

We implement each experimental design to fit with your needs, optimising output results to obtain high quality information.

CONTACT US

+34 677 49 59 70

+34 677 49 59 70

CONTACT US

JESÚS ESPADA

Co-founder

CSO. General Manager
Research & Development
PhD in Biological Sciences

+34 677 49 59 70
jesus.espada@skintargetbd.com

OUR SPECIALISTS

FROM OUR BLOG

CONTACT INFO

Madrid Scientific Park (Parque Científico de Madrid) Faraday 7, Fuencarral-El Pardo 28049 Madrid, Spain

Whatsapp

+34 677 49 59 70

Email

 info@sintargetbd.com

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